WG Burgstaller

Fungal Physiology WG Burgstaller

Physiology of overflow metabolism (i. e. the excretion of organic acids) in filamentous fungi; batch and continuous cultivation of filamentous fungi in bioreactors; rapid sampling and rapid stop of metabolism; model organism Penicillium ochrochloron.

We study overflow metabolism at the cellular levels of growth rate / growth phases, energy metabolism, electron transport chain and plasma membrane transport.

Topics

  • Physiology of filamentous fungi
  • Excretion of organic acids
  • Energy metabolism

Technologies

  • Highly standardized continuous and batch culture bioreactor cultivation of filamentous fungi
  • Rapid sampling and stop of metabolism
  • Metabolite analysis
  • High resolution respirometry
  • Plasma membrane purification

Key Publications

Gallmetzer M., Burgstaller W. (2002) Efflux of organic acids in Penicillium simplicissimum is an energy spilling process adjusting the catabolic carbon flow to nutrient supply and activity of catabolic pathways. Microbiology 148, 1143-1149. http://dx.doi.org/10.1099/00221287-148-4-1143
Vrabl P., Mutschlechner W., Burgstaller W. (2009) Dynamics of adenine nucleotides and energy charge during uncoupling of catabolism and anabolism in Penicillium ochrochloron. Mycological Research, 113, 1422-1432. http://dx.doi.org/10.1016/j.mycres.2009.09.011
Schinagl C. W., Vrabl P., Burgstaller W. (2016) Adapting high-resolution respirometry to glucose-limited steady state mycelium of the filamentous fungus Penicillium ochrochloron: Method development and standardization. Plos One 11(1): e0146878. http://dx.doi.org/10.1371/journal.pone.0146878

Group Leader

A. Univ. Prof. Dr. Wolfgang Burgstaller

University of Innsbruck

Institute of Microbiology

Technikerstraße 25, 6020 Innsbruck

0043 (0)512 507 51234

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Group Members

  • Dr. Pamela Vrabl

    Post Doc; Triggering bioactive metabolite production in fungi by co-cultivation and epigenetic modification This email address is being protected from spambots. You need JavaScript enabled to view it.
  • Mag. Christoph Schinagl

    PhD student; Electron transport chain in Penicillium ochrochloron under organic acid excreting and non-excreting conditions This email address is being protected from spambots. You need JavaScript enabled to view it.

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