Fungal Iron Homeostasis & Virulence

Our research interest is the characterization of fungal-specific pathways and regulatory circuits to improve therapy and diagnosis of fungal infections as well as the biotechnological potential of fungi. A major research focus is fungal iron homeostasis. Our studies revealed the essentiality of siderophore biosynthesis for virulence of Aspergillus fumigatus making the siderophore system an attractive target for improvement of antifungal therapy and diagnosis of fungal infections.

Homepage

Topics

  • Fungal iron homeostasis, iron sensing and siderophore metabolism
  • Fungal virulence determinants
  • Fungal secondary metabolism

Projects

  • The interplay between iron and TOR regulation
  • The potential of siderophores for diagnosis of fungal infections
  • Iron sensing in Aspergillus fumigatus
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  • Identification of pathways that are essential for virulence of Aspergillus fumigatus

Technologies

  • Genetic engineering of filamentous fungi (deletion, mutation, conditional expression, tagging)
  • Phenotyping of mutant strains
  • Gene expression analysis (transcriptomics, qRT-PCR, Northern, proteomics, Western)
  • Subcellular localization of proteins (via GFP-tagging)
  • Siderophore analysis

Key Publications

Gsaller F, Hortschansky P, Beattie SR, Klammer K, Tuppatsch K, Lechner BE, Rietzschel N, Werner ER, Vogan AA, Chung D, Mühlenhoff U, Kato M, Cramer RA, Brakhage AA, Haas H (2014). The Janus transcription factor HapX controls fungal adaptation to both iron starvation and iron excess. EMBO J, 33:2261-76
Haas H, Decristoforo (2015). An iron-mimicking Trojan horse as fungi´s Achilles heel - has the time come for molecular imaging of fungal infections? (2014). PLoS Pathogens, 11(1):e1004568
Dietl A-M, Amich J, Leal S, Beckmann N, Binder U, Beilhack A, Pearlman E, Haas H (2016). Histidine biosynthesis plays a crucial role in metal homeostasis and virulence of Aspergillus fumigatus. Virulence 6:1-12

 

Group Leader

ao.Univ.-Prof. Mag. Dr. Hubertus Haas

Medical University of Innsbruck

Division of Molecular Biology

Innrain 80-82/III, 6020 Innsbruck

+43 512 9003 70201

This email address is being protected from spambots. You need JavaScript enabled to view it.

Group Members

  • Beate Abt

    Technician; This email address is being protected from spambots. You need JavaScript enabled to view it.
  • Anna-Maria Dietl, MSc

    PhD student, Research topic: Identification of virulence determinants of A. fumigatus. This email address is being protected from spambots. You need JavaScript enabled to view it.
  • Fabio Gsaller, PhD

    PostDoc, Research Topic: Antifungal resistance in Aspergillus fumigauts. This email address is being protected from spambots. You need JavaScript enabled to view it.
  • Matthias Misslinger, MSc

    PhD student, Research topic: Fungal iron sensing. This email address is being protected from spambots. You need JavaScript enabled to view it.
  • Thomas Orasch, MSc

    PhD student, Research topic: Siderophore-based diagnosis of fungal infections. This email address is being protected from spambots. You need JavaScript enabled to view it.
  • Dr. Manuel Sanchez Lopez-Berges, PhD

    PostDoc, Research Topic: The interplay between iron and TOR regulation. This email address is being protected from spambots. You need JavaScript enabled to view it.

Get In Touch

Feel free to contact us:

  • Email: admin@mycologytyrol.org
  • Facebook: facebook.com/mycologytyrol
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