Antifungal Protein Research

Our main scientific interest lies in the identification and characterization of antimicrobial proteins secreted by filamentous ascomycetes. These proteins are small in size, cationic and contain 6-8 cysteines which form disulphide bonds that are important for correct protein folding and high stability against harsh environmental conditions. These bioactive proteins are promising candidates for new antimicrobial strategies and the development of novel drugs.

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Topics

  • Characterization of Antimicrobial Proteins
  • Identification of New Antifungal Drug Targets
  • Structure-Function Analyses of Cationic and Cysteine-rich Antimicrobial Proteins

Technologies

  • Antimicrobial activity assays
  • Site-directed mutagenesis
  • State-of-the-art molecular biology techniques
  • Expression and purification of recombinant proteins
  • Microscopy

Key Publications

Hegedüs, N., and Marx, F. (2013). Antifungal proteins: More than antimicrobials? Fungal Biol. Rev. 26: 132-145
Fizil, Á., Gáspári, Z., Barna, T., Marx, F., and Batta, G. (2015). "Invisible" conformers of an antifungal disulfide protein revealed by constrained cold an heat unfolding, CEST-NMR experiments, and molecular dynamics calculations. Chemistry 21: 5136-5144
Binder, U., Bencina, M., Fizil, Á., Batta, G., Chhillar, A.K., and Marx, F. (2015). Protein kinase A signaling and calcium ions are major players in PAF mediated toxicity against Aspergillus niger. FEBS Lett. 589: 1266-1271

 

Group Leader

Ao. Univ. Prof. Mag. Florentine Marx-Ladurner

Medical University of Innsbruck

Division of Molecular Biology

Innrain 80-82, 6020 Innsbruck

+43-(0)512-900370207

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Group Members

  • László Galgóczi, MSc, PhD

    Senior Post-doc,Research topic: Investigation of the role of distinct protein motifs in the Neosartorya fischeri antifungal protein NFAP that regulate disulphide bond formation, correct protein folding and antifungal activity. This email address is being protected from spambots. You need JavaScript enabled to view it.
  • Christoph Sonderegger, MSc

    PhD student, Research topic: Characterization of protein motifs of the Penicillium chrysogenum antifungal protein PAF that determine the antifungal activity. This email address is being protected from spambots. You need JavaScript enabled to view it.
  • Anna Huber, MSc

    PhD student, Research topic: Identification of fungal cell targets that mediate the toxicity of antifungal proteins. This email address is being protected from spambots. You need JavaScript enabled to view it.
  • Doris Bratschun-Khan, technician

    This email address is being protected from spambots. You need JavaScript enabled to view it.

Get In Touch

Feel free to contact us:

  • Email: admin@mycologytyrol.org
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