Immunology of fungal infections

Innate immunity is a central host defence against fungal infections since it can immediately react on a broad spectrum of fungal species. We concentrate on two innate immune weapons, complement and platelets. Studying the human pathogens Aspergillus, Candida and mucormycetes we analyse complement activation and platelet stimulation in vitro as well as in vivo.

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Topics

  • Antifungal immunity
  • Host-pathogen interaction
  • Immunotherapy

Projects

  • Platelet activation by fungal supernatants
  • Complement and platelets in fungal pathogenesis
  • Immunotherapeutic approaches against invasive fungal infections

Technologies

  • FACS
  • ELISA
  • Mouse models
  • Isolation of immune cells
  • Fluorescence microscopy

Key Publications

Speth C, Rambach G, Würzner R, Lass-Flörl C, Kozarcanin H, Hamad OA, Nilsson B, Ekdahl KN. Complement and platelets: Mutual interference in the immune network. Mol Immunol. 67:108-18 (2015)
Rambach G, Blum G, Latgé JP, Fontaine T, Heinekamp T, Hagleitner M, Jeckström H, Weigel G, Würtinger P, Pfaller K, Krappmann S, Löffler J, Lass-Flörl C, Speth C. Identification of Aspergillus fumigatus Surface Components That Mediate Interaction of Conidia and Hyphae With Human Platelets. J Infect Dis. 212:1140-9 (2015)
Speth C, Rambach G, Lass-Flörl C. Platelet immunology in fungal infections. Thromb Haemost. 112(4):632-9 (2014)

 

Group Leader

ao.Univ.-Prof. Dr. Cornelia Speth

Medical University of Innsbruck

Division of Hygiene and Medical Microbiology

Schöpfstraße 41, 6020 Innsbruck

0043-512-9003-70705

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Group Members

  • Günter Rambach, Mag. Dr.rer.nat.

    PostDoc, Research topic: Innate immunity in fungal infections; Platelet and complement activation in fungal infections. This email address is being protected from spambots. You need JavaScript enabled to view it.
  • Hemalata Deshmukh, MSc

    PhD student, Research topic: Relevance of platelet and complement system for the pathogenesis of invasive fungal infection; Immunopathogenesis of aspergillosis and mucormycosis. This email address is being protected from spambots. You need JavaScript enabled to view it.
  • Magdalena Hagleitner, Mag.

    Technician (in maternity leave), This email address is being protected from spambots. You need JavaScript enabled to view it.
  • Nadia Parth, MSc

    Technician, This email address is being protected from spambots. You need JavaScript enabled to view it.
  • Verena Fleischer, BSc

    Technician, This email address is being protected from spambots. You need JavaScript enabled to view it.
  • Verena Harpf, BSc

    Master student, Research topic: Pathogenesis and immunology of invasive mucormycosis; In vivo study of fungal infections and analysis of immunologic parameters. This email address is being protected from spambots. You need JavaScript enabled to view it.

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