Fungal Iron Homeostasis & Virulence

Working Group of Hubertus Haas

About

Our research interest is the characterization of fungal-specific pathways and regulatory circuits to improve therapy and diagnosis of fungal infections as well as the biotechnological potential of fungi. A major research focus is fungal iron homeostasis. Our studies revealed the essentiality of siderophore biosynthesis for virulence of Aspergillus fumigatus making the siderophore system an attractive target for improvement of antifungal therapy and diagnosis of fungal infections.

Homepage

- Fungal iron homeostasis, iron sensing and siderophore metabolism
- Fungal virulence determinants
- Fungal secondary metabolism
- Genetic manipulation of Aspergillus spp. - gene deletions, knock-ins, site-directed mutagenesis, conditional expression mutants
- Subcellular localization of proteins via GFP-tagging
- Gene expression analysis - reporter assays, qRT-PCR, Northern analysis
- Phenotypical analysis of mutant strains
- Siderophore analysis
→ Show all publications on PubMed

Projects

The interplay between iron and TOR regulation

The potential of siderophores for diagnosis of fungal infections

Iron sensing in Aspergillus fumigatus

People

Group Leader

ao.Univ.-Prof. Mag. Dr. Hubertus Haas

Medical University of Innsbruck - Division of Molecular Biology
Hubertus.haas@i-med.ac.at
+43 512 9003 70201

Group Members

Beate Abt

Technician; sigrid.abt@i-med.ac.at

Annie Yap, MSc

PhD student; annie.yap@i-med.ac.at

Matthias Misslinger, MSc

PhD student, Research topic: Fungal iron sensing. matthias.misslinger@i-med.ac.at

Jose Mario Mamede Aguiar Filho, MSc

PhD student; Molecular characterization of siderophore uptake in Aspergillus fumigatus; mario.aguiar@i-med.ac.at