Fungal Iron Homeostasis & Virulence

Working Group of Hubertus Haas

About

Our research interest is the characterization of fungal-specific pathways and regulatory circuits to improve therapy and diagnosis of fungal infections as well as the biotechnological potential of fungi. A major research focus is fungal iron homeostasis. Our studies revealed the essentiality of siderophore biosynthesis for virulence of Aspergillus fumigatus making the siderophore system an attractive target for improvement of antifungal therapy and diagnosis of fungal infections.

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- Fungal iron homeostasis, iron sensing and siderophore metabolism
- Fungal virulence determinants
- Fungal secondary metabolism
- Genetic manipulation of Aspergillus spp. - gene deletions, knock-ins, site-directed mutagenesis, conditional expression mutants
- Subcellular localization of proteins via GFP-tagging
- Gene expression analysis - reporter assays, qRT-PCR, Northern analysis
- Phenotypical analysis of mutant strains
- Siderophore analysis
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