Antifungal Protein Research

Working Group of Florentine Marx-Ladurner

About

Our main scientific interest lies in the identification and characterization of antimicrobial proteins secreted by filamentous ascomycetes. These proteins are small in size, cationic and contain 6-8 cysteines which form disulphide bonds that are important for correct protein folding and high stability against harsh environmental conditions. These bioactive proteins are promising candidates for new antimicrobial strategies and the development of novel drugs.

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- Characterization of Antimicrobial Proteins
- Identification of New Antifungal Drug Targets
- Structure-Function Analyses of Cationic and Cysteine-rich Antimicrobial Proteins
- Antimicrobial activity assays
- Site-directed mutagenesis
- State-of-the-art molecular biology techniques
- Expression and purification of recombinant proteins
- Microscopy
- Activity assays of histone-modifying enzymes
→ Show all publications on PubMed

Projects

HOROS – Host Response in Opportunistic Infections (FWF Doctoral Program) - Infection & Immunity: Innate Immunity – Host & Pathogen, Antifungal Host Response. Scientists and physicians of the Innsbruck campus, working in the related fields of Infection, Immunity, Transplantation and/or Biogerontology decided to join forces and created a structured and multidisciplinary research and training programme of excellence.

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The gamma-core motif of antifungal proteins from Ascomycetes - The accomplishment of our objectives will allow important new insights into the functional and structural role of the highly conserved gamma-core motif and provide the first steps towards a biotechnological application by developing bioactive molecules with worldwide economic and societal impact.

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People

Group Leader

Ao. Univ. Prof. Mag. Florentine Marx-Ladurner

Medical University of Innsbruck - Division of Molecular Biology
florentine.marx@i-med.ac.at
+43 512 9003 70207

Group Members

Doris Bratschun-Khan

Technician; doris.bratschun@i-med.ac.at

Cristina Schöpf, BSc

MSc student

Jeanett Holzknecht, MSc

PhD Student; jeanett.holzknecht@i-med.ac.at

Anant Kakar, MSc

PhD Student; anant.kakar@i-med.ac.at