Immunology of fungal infections
Innate immunity is a central host defence against fungal infections since it can immediately react on a broad spectrum of fungal species. We concentrate on two innate immune weapons, complement and platelets. Studying the human pathogens Aspergillus, Candida and mucormycetes we analyse complement activation and platelet stimulation in vitro as well as in vivo.
- Antifungal immunity
- Host-pathogen interaction
- Platelet activation by fungal supernatants
- Complement and platelets in fungal pathogenesis
- Immunotherapeutic approaches against invasive fungal infections
- Mouse models
- Isolation of immune cells
- Fluorescence microscopy
Speth C, Rambach G, Würzner R, Lass-Flörl C, Kozarcanin H, Hamad OA, Nilsson B, Ekdahl KN. Complement and platelets: Mutual interference in the immune network. Mol Immunol. 67:108-18 (2015)
Rambach G, Blum G, Latgé JP, Fontaine T, Heinekamp T, Hagleitner M, Jeckström H, Weigel G, Würtinger P, Pfaller K, Krappmann S, Löffler J, Lass-Flörl C, Speth C. Identification of Aspergillus fumigatus Surface Components That Mediate Interaction of Conidia and Hyphae With Human Platelets. J Infect Dis. 212:1140-9 (2015)
Speth C, Rambach G, Lass-Flörl C. Platelet immunology in fungal infections. Thromb Haemost. 112(4):632-9 (2014)
ao.Univ.-Prof. Dr. Cornelia Speth
Medical University of Innsbruck
Division of Hygiene and Medical Microbiology
Schöpfstraße 41, 6020 Innsbruck
Günter Rambach, Mag. Dr.rer.nat.
Hemalata Deshmukh, MSc
Magdalena Hagleitner, Mag.
Nadia Parth, MSc
Verena Fleischer, BSc
Verena Harpf, BSc